tailieunhanh - Báo cáo khoa học: " Radiotherapy and radiosurgery for benign skull base meningiomas"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Radiotherapy and radiosurgery for benign skull base meningiomas. | Radiation Oncology BioMed Central Open Access Review Radiotherapy and radiosurgery for benign skull base meningiomas Giuseppe Minniti 1 2 Maurizio Amichetti3 and Riccardo Maurizi Enrici1 Address Department of Radiotherapy Oncology Sant Andrea Hospital University La Sapienza Rome Italy 2Department of Neurosurgical Sciences Neuromed Institute Pozzilli IS Italy and 3ATreP- Provincial Agency for Proton Therapy Trento Italy Email Giuseppe Minniti - gminniti@ Maurizio Amichetti - amichetti@ Riccardo Maurizi Enrici - Corresponding author Published 14 October 2009 Received 17 July 2009 Accepted 14 October 2009 Radiation Oncology 2009 4 42 doi 1748-717X-4-42 This article is available from http content 4 1 42 2009 Minniti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal but frequently at a cost of treatment related high morbidity. Local control following subtotal excision of benign meningiomas can be improved with conventional fractionated external beam radiation therapy with a reported 5-year progression-free survival up to 95 . New radiation techniques including stereotactic radiosurgery SRS fractionated stereotactic radiotherapy FSRT and intensity-modulated radiotherapy IMRT have been developed as a more accurate technique of irradiation with more precise tumor localization and consequently a reduction in the volume of normal brain irradiated to high radiation doses. SRS achieves a high tumour control rate in the range of 85-97 at 5 years although it should be .