tailieunhanh - Báo cáo khoa học: " Neoadjuvant radiotherapy of primary irresectable unicentric Castleman’s disease: a case report and review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Neoadjuvant radiotherapy of primary irresectable unicentric Castleman’s disease: a case report and review of the literature. | de Vries et al. Radiation Oncology 2010 5 7 http content 5 1 7 RADIATION ONCOLOGY CASE REPORT Open Access Neoadjuvant radiotherapy of primary irresectable unicentric Castleman s disease a case report and review of the literature Iris AC de Vries1 Marjolein MS van Acht1 Thomas BJ Demeyere2 Marnix LM Lybeert3 Jean-Paul de Zoete1 Grard AP Nieuwenhuijzen1 Abstract Background Castleman disease CD is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. The etiology of this disorder is unclear although the histopathological presentation can be differentiated into a hyaline vascular variant a plasma cell variant and a mixed variant. Clinically it has been recorded that 3 manifestations of CD are characterized a localized unicentric type a generalized multicentric type and a mixed form. Surgery remains the main treatment for resectable unicentric CD since removal of the large node is possible without further complications. No consensus has been reached concerning the most adequate treatment for irresectable unicentric CD. Methods Case report of a 67 year old woman. Results This report describes the case of a 67-year-old woman with unicentric Castleman disease located in the right lower abdomen. The patient had symptoms of fatigue dyspnoea and pain in the right lower abdomen. Computed tomography CT - examination revealed a tumour which had grown to form a close relationship with the common iliac vessels and the sacral bone. A Laparotomy procedure revealed that the tumour was an irresectable mass. Neo-adjuvant radiotherapy 40 Gy was administered in order to downsize the tumour. Six weeks later a new CT-scan revealed a major reduction of the tumour which enabled a successful radical resection of the tumour to be performed. Histopathological analysis of the tumour showed the hyaline vascular type of CD. Conclusions Neo-adjuvant radiotherapy should be considered in case of an .