tailieunhanh - Báo cáo khoa học: "Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data rom randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: "Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data rom randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01). | Radiation Oncology BioMed Central Open Access Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation SQNP-01 Susan Li Er Loong1 3 Jacqueline Siok Gek Hwang2 Hui Hua Li4 Joseph Tien Seng Wee1 4 Swee Peng Yap1 Melvin Lee Kiang Chua1 Kam Weng Fong1 and Terence Wee Kiat Tan 1 Address Department of Radiation Oncology National Cancer Centre Singapore 2Department of Pathology Singapore General Hospital Singapore 3Divison of Cellular and Molecular Research National Cancer Centre Singapore and 4Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore Email Susan Li Er Loong - drsloong@ Jacqueline Siok Gek Hwang - gpthsg@ Hui Hua Li - ctelhh@ Joseph Tien Seng Wee - trdwts@ Swee Peng Yap - ntrysp@ Melvin Lee Kiang Kam Weng Fong - trdfkw@ Terence Wee Kiat Tan - trdtwk@ Corresponding author Published 10 July 2009 Received 10 April 2009 Radiation Oncology 2009 4 23 doi 1748-717X-4-23 Accepted 10 July 2009 This article is available from http content 4 1 23 2009 Loong et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Over-expression of cyclooxygenase-2 COX-2 enzyme has been reported in nasopharyngeal carcinoma NPC . However the prognostic significance of this has yet to be conclusively determined. Thus from our randomized trial of radiation versus concurrent chemoradiation in endemic NPC we analyzed a cohort of tumour samples collected from participants from one referral hospital. Methods 58 out of 88 patients