tailieunhanh - Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biological therapy in early arthritis – overtreatment or the way to go? | Available online http content 9 3 211 Review Aspects of early arthritis Biological therapy in early arthritis - overtreatment or the way to go Kei Ikeda Sally Cox and Paul Emery Academic Unit of Musculoskeletal Disease Leeds University Chapel Allerton Hospital Chapeltown Road Leeds LS7 4SA UK Corresponding author Paul Emery Published 24 May 2007 This article is online at http content 9 3 211 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 211 doi ar2177 Abstract The availability of newer and more expensive therapies for patients with rheumatoid arthritis has changed treatment beyond recognition. Disease remission is the goal for all new patients. Studies have shown that a combination of tumour necrosis factor TNF -blocking drugs and methotrexate produces superior outcomes over monotherapy alone however use is limited by cost and potential side-effects. Currently anti-TNF therapy is normally reserved for patients who have failed traditional disease-modifying anti-rheumatic drugs. The question that remains is whether TNF-blocking drugs are better used if given early the high direct costs are countered by both direct and indirect savings in healthcare costs from optimal control of disease and the benefits of early control outweigh the increased risk of infection and malignancy. Introduction Rheumatoid arthritis RA is a progressive destructive inflammatory disease associated with pain and disability. It has a significant negative impact on quality of life with job loss and poor social functioning as well as resultant healthcare costs to the community. Management of RA has changed considerably within the past decade recognition that earlier treatment provides superior outcomes 1-5 combined with the availability of potent biological agents has focused treatment aims on the induction of remission instead of simply controlling symptoms. Conventional therapy with disease-modifying .

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