tailieunhanh - Báo cáo khoa học: " Pre-segmented 2-Step IMRT with subsequent direct machine parameter optimisation – a planning study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Pre-segmented 2-Step IMRT with subsequent direct machine parameter optimisation – a planning study. | Radiation Oncology BioMed Central Research Pre-segmented 2-Step IMRT with subsequent direct machine parameter optimisation - a planning study Klaus Bratengeier 1 Jurgen Meyert2 and Michael Flentjef1 Open Access Address 1Klinik und Poliklinik fur Strahlentherapie Universitat Wurzburg Josef-Schneider-Str. 11 97080 Wurzburg Germany and 2Department of Physics and Astronomy University of Canterbury Private Bag 4800 Christchurch 8140 New Zealand Email Klaus Bratengeier - Bratengeier_K@ Jurgen Meyer - Michael Flentje - Flentje_M@ Corresponding author tEqual contributors Published 6 November 2008 Radiation Oncology 2008 3 38 doi l748-7l7X-3-38 Received 4 June 2008 Accepted 6 November 2008 This article is available from http content 3 l 38 2008 Bratengeier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Modern intensity modulated radiotherapy IMRT mostly uses iterative optimisation methods. The integration of machine parameters into the optimisation process of step and shoot leaf positions has been shown to be successful. For IMRT segmentation algorithms based on the analysis of the geometrical structure of the planning target volumes PTV and the organs at risk OAR the potential of such procedures has not yet been fully explored. In this work 2-Step IMRT was combined with subsequent direct machine parameter optimisation DMPO-Raysearch Laboratories Sweden to investigate this potential. Methods In a planning study DMPO on a commercial planning system was compared with manual primary 2-Step IMRT segment generation followed by DMPO optimisation. l5 clinical cases and the ESTRO Quasimodo phantom were employed.