tailieunhanh - Báo cáo khoa học: " Normal tissue toxicity after small field hypofractionated stereotactic body radiation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Normal tissue toxicity after small field hypofractionated stereotactic body radiation. | Radiation Oncology BioMed Central Review Normal tissue toxicity after small field hypofractionated stereotactic body radiation Michael T Milano Louis S Constine and Paul Okunieff Address Department of Radiation Oncology University of Rochester Medical Center Rochester NY 14642 USA Email Michael T Milano - mtmilano@ Louis S Constine - louis_constine@ Paul Okunieff- paul_okunieff@ Corresponding author Open Access Published 31 October 2008 Received 22 August 2008 Accepted 31 October 2008 Radiation Oncology 2008 3 36 doi l748-7l 7X-3-36 This article is available from http content 3 l 36 2008 Milano et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Stereotactic body radiation SBRT is an emerging tool in radiation oncology in which the targeting accuracy is improved via the detection and processing of a three-dimensional coordinate system that is aligned to the target. With improved targeting accuracy SBRT allows for the minimization of normal tissue volume exposed to high radiation dose as well as the escalation of fractional dose delivery. The goal of SBRT is to minimize toxicity while maximizing tumor control. This review will discuss the basic principles of SBRT the radiobiology of hypofractionated radiation and the outcome from published clinical trials of SBRT with a focus on late toxicity after SBRT. While clinical data has shown SBRT to be safe in most circumstances more data is needed to refine the ideal dose-volume metrics. Introduction Stereotactic body radiation therapy SBRT uses novel technologies to more accurately localize radiation targets. The word .