tailieunhanh - Báo cáo khoa học: " Neuropsychological testing and biomarkers in the management of brain metastases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Neuropsychological testing and biomarkers in the management of brain metastases. | Radiation Oncology BioMed Central Open Access Review Neuropsychological testing and biomarkers in the management of brain metastases Andrew Baschnagel1 Pamela L Wolters2 and Kevin Camphausen 1 Address Radiation Oncology Branch National Cancer Institute National Institutes of Health 9000 Rockville Pike Building 10-CRC Room B2-3561 Bethesda Maryland 20892 USA and 2Medical Illness Counseling Center and National Cancer Institute National Institutes of Health Bethesda USA Email Andrew Baschnagel - amb26@ Pamela L Wolters - woltersp@ Kevin Camphausen - camphauk@ Corresponding author Published 17 September 2008 Received 28 May 2008 Accepted 17 September 2008 Radiation Oncology 2008 3 26 doi l748-7l 7X-3-26 This article is available from http content 3 l 26 2008 Baschnagel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Prognosis for patients with brain metastasis remains poor. Whole brain radiation therapy is the conventional treatment option it can improve neurological symptoms prevent and improve tumor associated neurocognitive decline and prevents death from neurologic causes. In addition to whole brain radiation therapy stereotactic radiosurgery neurosurgery and chemotherapy also are used in the management of brain metastases. Radiosensitizers are now currently being investigated as potential treatment options. All of these treatment modalities carry a risk of central nervous system CNS toxicity that can lead to neurocognitive impairment in long term survivors. Neuropsychological testing and biomarkers are potential ways of measuring and better understanding CNS toxicity. These tools may help optimize current therapies and develop new treatments for .