tailieunhanh - Báo cáo khoa học: "Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: "Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study. | Radiation Oncology BioMed Central Research Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland a pilot study David Goldblum 1 Pirus Ghadjar2 Juergen Curschmann2 Richard Greiner2 and Daniel Aebersold2 Address Department of Ophthalmology University Basel University Hospital Basel Switzerland and 2Department of Radiation Oncology University Bern Inselspital Bern Switzerland Email David Goldblum - dgoldblum@ Pirus Ghadjar - Juergen Curschmann - Richard Greiner - Daniel Aebersold - Corresponding author Open Access Published I September 2008 Radiation Oncology 2008 3 22 doi I748-717X-3-22 Received 24 April 2008 Accepted I September 2008 This article is available from http content 3 I 22 2008 Goldblum et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background To use amifostine concurrently with radiochemotherapy CT-RT or radiotherapy RT alone in order to prevent dry eye syndrome in patients with malignancies located in the fronto-orbital region. Methods Five patients 2 males 3 females with diagnosed malignancies Non-Hodgkin B-cell Lymphoma neuroendocrine carcinoma involving the lacrimal gland in which either combined CT-RT or local RT were indicated were prophylactically treated with amifostine 500 mg sc . Single RT fraction dose total dose and treatment duration were individually adjusted to the patient s need. Acute and late adverse effects were recorded using the RTOG score. Subjective and objective dry eye .