tailieunhanh - Báo cáo khoa học: " Highly proliferative neuroendocrine carcinoma – influence of radiotherapy fractionation on tumor response"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Highly proliferative neuroendocrine carcinoma – influence of radiotherapy fractionation on tumor response. | Radiation Oncology BioMed Central Open Access Short report Highly proliferative neuroendocrine carcinoma - influence of radiotherapy fractionation on tumor response Anne Hansen Ree1 2 Address 1Division of Cancer Medicine and Radiotherapy The Norwegian Radium Hospital Rikshospitalet University Hospital 0310 Oslo Norway and 2Faculty Division Akershus University Hospital University of Oslo 0318 Oslo Norway Email Anne Hansen Ree - Published 19 May 2008 Received 29 November 2007 Radiation Oncology 2008 3 13 doi l748-7l 7X-3-13 Accepted 19 May 2008 This article is available from http content 3 l l3 2008 Ree licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ A 45-year-old white male presented to our department with postoperative recurrence of gastrointestinal poorly differentiated neuroendocrine carcinoma manifesting as lymph node dissemination and a solitary implantation metastasis in the rectovesical pouch. Following disease progression on chemotherapy the patient was treated with radiotherapy using either a conventional daily treatment or an accelerated hyperfractionated protocol to separate sites of disease progression. Using serial CT scan assessment changes in cross-sectional area of the separately treated metastatic lesions were evaluated for determination of therapy response. The accelerated hyperfractionated radiotherapy appeared to limit the rate of tumor growth to a greater degree than the conventional fractionation schedule. Of uttermost importance in this palliative setting the patient completed the intensified radiotherapy regimens with acceptable acute toxicity. Given the proliferative