tailieunhanh - Báo cáo khoa học: "Successful radiopeptide targeting of metastatic anaplastic meningioma: Case report"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Successful radiopeptide targeting of metastatic anaplastic meningioma: Case report. | Sabet et al. Radiation Oncology 2011 6 94 http content 6 1 94 RADIATION ONCOLOGY CASE REPORT Open Access Successful radiopeptide targeting of metastatic anaplastic meningioma Case report 1 1 2 3 1 Amir Sabet Hojjat Ahmadzadehfar Ulrich Herrlinger Winfried Wilinek Hans-Jurgen Biersack and Samer Ezziddin1 Abstract A patient with anaplastic meningioma and lung metastases resistant to conventional treatment underwent radiopeptide therapy with 177Lu- DOTA-octreotate in our institute. The treatment resulted in significant improvement in patient s quality of life and inhibition of tumor progression. This case may eventually help to establish the value of radiopeptide therapy in patients with this rare condition. Keywords 18F-FDG-PET CT anaplastic meningioma 111In-DTPA-octreotide radio receptor therapy Background Meningiomas are generally slow-growing lesions that arise from intracranial and spinal meninges. They are usually perceived as benign tumours for which radical surgery is the treatment of choice 1 . However they may occasionally behave aggressively in atypical or malignant meningiomas invading the brain and or metastasising outside the CNS which occurs in only of all cases 2 . The most common extracranial location of metastasis is the lung followed by liver lymph nodes and bones 3 4 . Meningiomas present ideal targets for somatostatin receptor scintigraphy SRS with 111In-DTPA-octreotide. However the value of the radioreceptor therapy using radiolabeled somatostatin analog 177Lu-DOTA-octreotate is not yet well established in patients with metastasized or inoperable meningiomas 5 6 . Here we present a patient with metastatic anaplastic meningioma who benefited from radiopeptide targeting. Case presentation A 62 year old female with intracranial anaplastic meningioma was referred to our department for a restaging with 18F-fluorodeoxyglucose FDG -PET CT. The patient suffered from a protrusio bulbi of the left eye and progressive facial pain. No