tailieunhanh - Báo cáo khoa học: " Does Intensity Modulated Radiation Therapy (IMRT) prevent additional toxicity of treating the pelvic lymph nodes compared to treatment of the prostate only?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Does Intensity Modulated Radiation Therapy (IMRT) prevent additional toxicity of treating the pelvic lymph nodes compared to treatment of the prostate only?. | Radiation Oncology BioMed Central Research Does Intensity Modulated Radiation Therapy IMRT prevent additional toxicity of treating the pelvic lymph nodes compared to treatment of the prostate only Matthias Guckenberger Kurt Baier Anne Richter Dirk Vordermark and Michael Flentje Open Access Address Department of Radiation Oncology Julius-Maximilians University Wuerzburg Germany Email Matthias Guckenberger - Guckenberger_M@ Kurt Baier-Baier_K@ Anne Richter - Richter_A3@ Dirk Vordermark - Vordermark_D@ Michael Flentje - Flentje_M@ Corresponding author Published II January 2008 Radiation Oncology 2008 3 3 doi 1748-7I7X-3-3 Received 25 September 2007 Accepted I I January 2008 This article is available from http content 3 I 3 2008 Guckenberger et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background To evaluate the risk of rectal bladder and small bowel toxicity in intensity modulated radiation therapy IMRT of the prostate only compared to additional irradiation of the pelvic lymphatic region. Methods For ten patients with localized prostate cancer IMRT plans with a simultaneous integrated boost SIB were generated for treatment of the prostate only plan-PO and for additional treatment of the pelvic lymph nodes plan-WP . In plan-PO doses of 60 Gy and 74 Gy 33 fractions were prescribed to the seminal vesicles and to the prostate respectively. Three plans-WP were generated with prescription doses of 46 Gy Gy and 54 Gy to the pelvic target volume doses to the prostate and seminal vesicles were identical to plan-PO. The risk of rectal bladder and small bowel toxicity was .