tailieunhanh - Báo cáo khoa học: "Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: "Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?. | Radiation Oncology BioMed Central Research Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs Carsten Nieder 1 Adam Pawinski1 Nicolaus H Andratschke2 and Michael Molls2 Address 1Radiation Oncology Unit Nordlandssykehuset HF 8092 Bod0 Norway and 2Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universitat Munchen 81675 Munich Germany Email Carsten Nieder - cnied@ Adam Pawinski - Nicolaus H Andratschke - radiotherapy@ Michael Molls - klinik-fuer-strahlentherapie@ Corresponding author Open Access Published 10 January 2008 Received 12 October 2007 Radiation Oncology 2008 3 2 doi 1748-7I7X-3-2 Accepted 10 January 2008 This article is available from http content 3 1 2 2008 Nieder et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Androgen suppression treatment AST might increase the risk of cardiac morbidity in prostate cancer patients. Possible explanations were provided however they disregard the potential contribution of prophylactic radiotherapy to the mamillary regions PMRT prescribed to avoid gynecomastia . Methods We studied the exposure of the heart in a typical electron beam PMRT setting by evaluating computed tomography CT scans in 40 non-cancer patients age 65 and 75 years in 50 each and 17 prostate cancer patients. Five of the younger 7 of the older and 4 of the cancer patients had significant cardiac disease. Results The median distance between skin and outer heart contour decreased with age. In all three groups patients with cardiac morbidity had smaller distances. When using the CT-determined PMRT beam .