tailieunhanh - Báo cáo khoa học: " Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremitie"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities. | Curtis et al. Radiation Oncology 2011 6 91 http content 6 1 91 RADIATION ONCOLOGY RESEARCH Open Access Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities 1 2 3 3 2 Kelly K Curtis Jonathan B Ashman Christopher P Beauchamp Adam J Schwartz Matthew D Callister Amylou C Dueck4 Leonard L Gunderson 2 and Tom R Fitch1 Abstract Background Neoadjuvant chemoradiation NCR prior to resection of extremity soft tissue sarcoma STS has been studied but data are limited. We present outcomes with NCR using a variety of chemotherapy regimens compared to neoadjuvant radiation without chemotherapy NR and surgery alone SA . Methods We conducted a retrospective chart review of 112 cases. Results Treatments included SA 36 patients NCR 39 patients and NR 37 patients . NCR did not improve the rate of margin-negative resections over SA or NR. Loco-regional relapse-free survival distant metastases-free survival and overall survival OS were not different among the treatment groups. Patients with relapsed disease OR p and tumor size greater than 5 cm OR p were more likely to have a loco-regional recurrence on logistic regression analysis. Significantly increased OS was found among NCR-treated patients with tumors greater than 5 cm compared to SA 3 year OS 69 vs. 40 p . Wound complication rates were higher after NCR compared to SA 50 vs. 11 p but not compared to NR p . Wet desquamation was the most common adverse event of NCR. Conclusions NCR and NR are acceptable strategies for patients with STS. NCR is well-tolerated but not clearly superior to NR. Keywords Neoadjuvant chemotherapy radiation chemoradiation soft tissue sarcoma extremity Background Extremity soft tissue sarcoma STS treatment strategies gradually have shifted away from amputation toward a limb preservation approach. For most patients with low-grade extremity STS . T1-2 N0 M0 .