tailieunhanh - Báo cáo khoa học: "Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study. | Villà et al. Radiation Oncology 2011 6 23 http content 6 1 23 RADIATION ONCOLOGY RESEARCH Open Access Validation of the new graded prognostic assessment scale for brain metastases a multicenter prospective study 1 2 11 2 1 Salvador Villà Damien C Weber Cristina Moretones Anabel Manes Christophe Combescure Josep Jové Dsỉlr mTỉ Di i 2Ifm3 I iTỉHrTỉc3 ImrHi Rn irM R omor5 Csưmci Rolan 2s1 Ennrocr fEr i IC6 Paioma ruyalto rauicia Cuadias Joidi Biuna Eugenia veigei Caime Daiaiià riancesc Giaus Abstract Background Prognostic indexes are useful to guide tailored treatment strategies for cancer patients with brain metastasis BM . We evaluated the new Graded Prognostic Assessment GPA scale in a prospective validation study to compare it with two published prognostic indexes. Methods A total of 285 newly diagnosed BM n 85 with synchronous BM patients accrued prospectively between 2000 and 2009 were included in this analysis. Mean age was 62 years. The median KPS and number of BM was 70 range 20-100 and 3 range 1-50 respectively. The majority of primary tumours were lung 53 or breast 17 cancers. Treatment was administered to 255 patients. Only a minority of patients could be classified prospectively in a favourable prognostic class GPA recursive partitioning analysis RPA 1 and Basic Score for BM BSBM 3 . Mean follow-up FU time was months. Results During the period of FU 225 patients died. The 6 months- and 1 year-OS was and respectively. On multivariate analysis performance status P BSBM P Center P RPA P and GPA P were statistically significant for OS. The survival prediction performances of all indexes were identical. Noteworthy the significant OS difference observed within 3 months of diagnosis between the BSBM RPA and GPA classes groups was not observed after this cut-off time point. Harrell s concordance indexes C were and for the GPA BSBM and RPA respectively.

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