tailieunhanh - Báo cáo khoa học: " Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003 - a single institution’s experience"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003 - a single institution’s experience. | Stoiber et al. Radiation Oncology 2010 5 122 http content 5 1 122 RADIATION ONCOLOGY RESEARCH Open Access Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003 - a single institution s experience 1 1 1 13 1 Eva Maria Stoiber Benjamin Schaible Klaus Herfarth Daniela Schulz-Ertner Peter E Huber Jurgen Debus Susanne Oertel1 Abstract Background To evaluate the effectivity of fractionated radiotherapy in adolescent and adult patients with pineal parenchymal tumors PPT . Methods Between 1982 and 2003 14 patients with PPTs were treated with fractionated radiotherapy. 4 patients had a pineocytoma PC one a PPT with intermediate differentiation PPTID and 9 patients a pineoblastoma PB 2 of which were recurrences. All patients underwent radiotherapy on the primary tumor site with a median total dose of 54 Gy. In 9 patients with primary PB treatment included whole brain irradiation 3 patients or irradiation of the craniospinal axis 6 patients with a median total dose of 35 Gy. Results Median follow-up was 123 months in the PC patients and 109 months in the patients with primary PB. 7 patients were free from relapse at the end of follow-up. One PC patient died from spinal seeding. Among 5 PB patients treated with radiotherapy without chemotherapy 3 developed local or spinal tumor recurrence. Both patients treated for PB recurrences died. The patient with PPTID is free of disease 7 years after radiotherapy. Conclusion Local radiotherapy seems to be effective in patients with PC and some PPTIDs. Diagnosis and treatment of patients with more aggressive variants of PPTIDs as well as treatment of PB needs to be further improved since local and spinal failure even despite craniospinal irradiation CSI is common. As PPT are very rare tumors treatment within multi-institutional trials remains necessary. Background The pineal gland is an endocrine gland which is responsible for

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