tailieunhanh - Báo cáo khoa học: " Assessment of peri- and postoperative complications and Karnofsky-performance status in head and neck cancer patients after radiation or chemoradiation that underwent surgery with regional or free-flap reconstruction for salvage, palliation, or to improve function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Assessment of peri- and postoperative complications and Karnofsky-performance status in head and neck cancer patients after radiation or chemoradiation that underwent surgery with regional or free-flap reconstruction for salvage, palliation, or to improve function. | Simon et al. Radiation Oncology 2011 6 109 http content 6 1 109 RADIATION ONCOLOGY SHORT REPORT Open Access Assessment of peri- and postoperative complications and Karnofsky-performance status in head and neck cancer patients after radiation or chemoradiation that underwent surgery with regional or free-flap reconstruction for salvage palliation or to improve function 1 1 1 2 2 1 Christian Simon Cem Bulut Philippe A Federspil Marc W Munter Katja Lindel Zazie Bergmann Serkan Sertel1 Sarah Leitzbach1 and Peter K Plinkert1 Abstract Background Surgery after chemo radiation RCTX RTX is felt to be plagued with a high incidence of wound healing complications reported to be as high as 70 . The additional use of vascularized flaps may help to decrease this high rate of complications. Therefore we examined within a retrospective single-institutional study the peri and postoperative complications in patients who underwent surgery for salvage palliation or functional rehabilitation after chemo radiation with regional and free flaps. As a second study end point the Karnofsky performance status KPS was determined preoperatively and 3 months postoperatively to assess the impact of such extensive procedures on the overall performance status of this heavily pretreated patient population. Findings 21 patients were treated between 2005 and 2010 in a single institution 17 male 4 female for salvage 10 21 palliation 4 21 or functional rehabilitation 7 21 . Overall 23 flaps were performed of which 8 were free flaps. Major recipient site complications were observed in only 4 pts. 19 1 postoperative haemorrhage 1 partial flap loss 2 fistulas and major donor site complications in 1 pt wound dehiscence . Also 2 minor donor site complications were observed. The overall complication rate was 33 . There was no free flap loss. Assessment of pre- and postoperative KPS revealed improvement in 13 out of 21 patients 62 . A decline of KPS was noted in only one patient. Conclusions

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