tailieunhanh - Báo cáo khoa học: "The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer. | Palma et al. Radiation Oncology 2010 5 119 http content 5 1 119 RADIATION ONCOLOGY RESEARCH Open Access The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer Pablo Palma 1 Raquel Conde-Muíno1 Antonio Rodríguez-Fernández2 Inmaculada Segura-Jimenez1 Rocío Sánchez-Sánchez2 Javier Martín-Cano1 Manuel Gómez-Río2 José A Ferron1 José M Llamas-Elvira2 Abstract Background We aim to investigate the possibility of using 18F-positron emission tomography computer tomography PET-CT to predict the histopathologic response in locally advanced rectal cancer LARC treated with preoperative chemoradiation CRT . Methods The study included 50 patients with LARC treated with preoperative CRT. All patients were evaluated by PET-CT before and after CRT and results were compared to histopathologic response quantified by tumour regression grade patients with TRG 1-2 being defined as responders and patients with grade 3-5 as nonresponders . Furthermore the predictive value of metabolic imaging for pathologic complete response ypCR was investigated. Results Responders and non-responders showed statistically significant differences according to Mandard s criteria for maximum standardized uptake value SUVmax before and after CRT with a specificity of 76 6 and a positive predictive value of 66 7 . Furthermore SUVmax values after CRT were able to differentiate patients with ypCR with a sensitivity of 63 and a specificity of 74 4 positive predictive value 41 2 and negative predictive value 87 9 This rather low sensitivity and specificity determined that PET-CT was only able to distinguish 7 cases of ypCR from a total of 11 patients. Conclusions We conclude that 18-F PET-CT performed five to seven weeks after the end of CRT can visualise functional tumour response in LARC. In contrast metabolic imaging with 18-F PET-CT is not able to predict patients with ypCR accurately. Background Over the past decade neoadjuvant .