tailieunhanh - Báo cáo khoa học: "Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity. | Ferrigno et al. Radiation Oncology 2010 5 117 http content 5 1 117 RADIATION ONCOLOGY RESEARCH Open Access Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity 1 2 2 1 1 Robson Ferrigno Adriana Santos Lidiane C Martins Eduardo Weltman Michael J Chen Roberto Sakuraba3 Cleverson P Lopes3 José C Cruz3 Abstract Background This retrospective analysis reports on the comparative outcome of acute gastrointestinal GI and genitourinary GU toxicities between conformal radiation therapy CRT and intensity modulated radiation therapy IMRT techniques in the treatment of patients with pelvic tumors. Methods From January 2002 to December 2008 69 patients with pelvic tumors underwent whole pelvic CRT and 65 underwent whole pelvic IMRT to treat pelvic lymph nodes and primary tumor regions. Total dose to the whole pelvis ranged from 50 to Gy in 25 to 28 daily fractions. Chemotherapy CT regimen when employed was based upon primary tumor. Acute GI and GU toxicities were graded by RTOG EORTC acute radiation morbidity criteria. Results Absence of GI symptoms during radiotherapy grade 0 was more frequently observed in the IMRT group versus p and medication for diarrhea Grade 2 was more frequently used in the CRT group versus p . Acute GI grade 1 and 3 side effects incidence was similar in both groups versus p and 0 versus p respectively . Incidence of GU toxicity was similar in both groups grade 0 versus p grade 1 20 versus p grade 2 versus p and grade 3 0 versus p . Conclusions This comparative case series shows less grade 2 acute GI toxicity in patients treated with whole pelvic IMRT in comparison with those treated with CRT. Incidence of acute GU toxicity was similar in both groups. Background Radiation therapy RT plays an important role in the treatment of malignant pelvic .