tailieunhanh - Báo cáo khoa học: " Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study. | Velenik et al. Radiation Oncology 2011 6 105 http content 6 1 105 RADIATION ONCOLOGY RESEARCH Open Access Neoadjuvant capecitabine radiotherapy and bevacizumab CRAB in locally advanced rectal cancer results of an open-label phase II study 1 11 2 11 1 Vaneja Velenik Janja Ocvirk Maja Music Matej Bracko Franc Anderluh Irena Oblak Ibrahim Edhemovic Erik Brecelj1 Mateja Kropivnik1 and Mirko Omejc2 Abstract Background Preoperative capecitabine-based chemoradiation is a standard treatment for locally advanced rectal cancer LARC . Here we explored the safety and efficacy of the addition of bevacizumab to capecitabine and concurrent radiotherapy for LARC. Methods Patients with MRI-confirmed stage II III rectal cancer received bevacizumab 5 mg kg . 2 weeks prior to neoadjuvant chemoradiotherapy followed by bevacizumab 5 mg kg on Days 1 15 and 29 capecitabine 825 mg m2 twice daily on Days 1-38 and concurrent radiotherapy Gy Gy day 5 days week for 5 weeks three Gy day starting on Day 1. Total mesorectal excision was scheduled 6-8 weeks after completion of chemoradiotherapy. Tumour regression grades TRG were evaluated on surgical specimens according to Dworak. The primary endpoint was pathological complete response pCR . Results 61 patients were enrolled median age 60 years range 31-80 64 male . Twelve patients had T3N0 tumours 1 patient T2N1 19 patients T3N1 2 patients T2N2 22 patients T3N2 and 5 patients T4N2. Median tumour distance from the anal verge was 6 cm range 0-11 . Grade 3 adverse events included dermatitis n 6 proteinuria n 4 and leucocytopenia n 3 . Radical resection was achieved in 57 patients 95 and 42 patients 70 underwent sphincter-preserving surgery. TRG 4 pCR was recorded in 8 patients and TRG 3 in 9 patients . T- N- and overall downstaging rates were and respectively. Conclusions This study demonstrates the feasibility of preoperative chemoradiotherapy with .