tailieunhanh - Báo cáo khoa học: "Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis. | Cao et al. Radiation Oncology 2011 6 104 http content 6 1 104 RADIATION ONCOLOGY RESEARCH Open Access Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma A more accurate and appropriate assessment of prognosis . -12 13 14 12 15 12 12 Xun Cao Rong-Zhen Luo Li-Ru He Yong Li Wen-Qian Lin You-Fang Chen and Zhe-Sheng Wen Abstract Background Lung metastases arising from nasopharyngeal carcinomas NPC have a relatively favourable prognosis. The purpose of this study was to identify the prognostic factors and to establish a risk grouping in patients with lung metastases from NPC. Methods A total of 198 patients who developed lung metastases from NPC after primary therapy were retrospectively recruited from January 1982 to December 2000. Univariate and multivariate analyses of clinical variables were performed using Cox proportional hazards regression models. Actuarial survival rates were plotted against time using the Kaplan-Meier method and log-rank testing was used to compare the differences between the curves. Results The median overall survival OS period and the lung metastasis survival LMS period were and months respectively. After univariate and multivariate analyses of the clinical variables age T classification N classification site of metastases secondary metastases and disease-free interval DFI correlated with OS whereas age VCA-IgA titre number of metastases and secondary metastases were related to LMS. The prognoses of the low- score 0-1 intermediate- score 2-3 and high-risk score 4-8 subsets based on these factors were significantly different. The 3- 5- and 10-year survival rates of the low- intermediate- and high-risk subsets respectively P were as follows 60 and 59 30 and and 7 and 0 . Conclusions In this study clinical variables provided prognostic indicators of survival in NPC patients with lung metastases. Risk subsets would help in a more accurate .