tailieunhanh - Báo cáo khoa học: "Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinom"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinoma. | Hsieh et al. Radiation Oncology 2010 5 40 http content 5 1 40 RADIATION ONCOLOGY RESEARCH Open Access Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinoma Chen-Hsi Hsieh1 6 Chia-Yuan Liu4 Pei-Wei Shueng1 7 Ngot-Swan Chong1 Chih-Jen Chen4 Ming-Jen Chen4 Ching-Chung Lin4 Tsang-En Wang4 Shee-Chan Lin4 Hung-Chi Tai3 Hui-Ju Tien1 Kuo-Hsin Chen2 Li-Ying Wang9 YenPing Hsieh10 David YC Huang 11 and Yu-Jen Chen 3 5 6 8 Abstract Background To compare the differences in dose-volume data among coplanar intensity modulated radiotherapy IMRT noncoplanar IMRT and helical tomotherapy HT among patients with hepatocellular carcinoma HCC and portal vein thrombosis PVT . Methods Nine patients with unresectable HCC and PVT underwent step and shoot coplanar IMRT with intent to deliver 46 - 54 Gy to the tumor and portal vein. The volume of liver received 30Gy was set to keep less than 30 of whole normal liver V30 30 . The mean dose to at least one side of kidney was kept below 23 Gy and 50 Gy as for stomach. The maximum dose was kept below 47 Gy for spinal cord. Several parameters including mean hepatic dose percent volume of normal liver with radiation dose at X Gy Vx uniformity index conformal index and doses to organs at risk were evaluated from the dose-volume histogram. Results HT provided better uniformity for the planning-target volume dose coverage than both IMRT techniques. The noncoplanar IMRT technique reduces the V10 to normal liver with a statistically significant level as compared to HT. The constraints for the liver in the V30 for coplanar IMRT vs. noncoplanar IMRT vs. HT could be reconsidered as 21 vs. 17 vs. 17 respectively. When delivering 50 Gy and 60-66 Gy to the tumor bed the constraints of mean dose to the normal liver could be less than 20 Gy and 25 Gy respectively. Conclusion Noncoplanar IMRT and HT are potential techniques of radiation therapy for HCC patients with .