tailieunhanh - Báo cáo khoa học: "Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients. | Gaber et al. Radiation Oncology 2011 6 100 http content 6 1 100 RADIATION ONCOLOGY RESEARCH Open Access Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients 12 3 1 2 Alexander Gaber Christina Stene Kristina Hotakainen Bjorn Nodin Ingrid Palmquist Anders Bjartell Ulf-Hakan Stenman3 Bengt Jeppsson2 Louis B Johnson2 and Karin Jirstrom1 Abstract Background We have previously demonstrated that elevated concentrations of tumour-associated trypsin inhibitor TATI in both tumour tissue t-TATI and in serum s-TATI are associated with a poor prognosis in colorectal cancer patients. It was also found that s-TATI concentrations were lower in patients with rectal cancer compared to patients with colon cancer. In this study we investigated the effects of neoadjuvant radiotherapy RT on concentrations of t-TATI and s-TATI in patients with rectal cancer. Methods TATI was analysed in serum normal mucosa and tumour tissue collected at various time points in 53 rectal cancer patients enrolled in a case-control study where 12 patients received surgery alone 20 patients 5x5 Gy short-term preoperative RT and 21 patients 25 x 2 Gy long-term preoperative RT. T-TATI was analysed by immunohistochemistry and s-TATI was determined by an immunofluorometric assay. Mann-Whitney U test and Wilcoxon Z Z test were used to assess t-TATI and s-TATI concentrations in relation to RT. Spearman s correlation R test was used to explore the associations between t-TATI s-TATI and clinicopathological parameters. Overall survival OS according to high and low t-TATI and s-TATI concentrations was estimated by classification and regression tree analysis Kaplan-Meier analysis and the log rank test. Results RT did not affect concentrations of t-TATI or s-TATI. In patients receiving short-term but not long-term RT s-TATI concentrations were significantly higher 4 weeks post surgery than