tailieunhanh - Báo cáo khoa học: "3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: 3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma. | Ren et al. Radiation Oncology 2010 5 113 http content 5 1 113 RADIATION ONCOLOGY RESEARCH Open Access 3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma Yu-Feng Ren1t Yuan-Hong GaoH Xin-Ping Cao1 Wei-Jun Ye1 Bin S Teh2 3 Abstract Background To compare the results of external beam radiotherapy in combination with 3D- computed tomography CT -implanted interstitial high dose rate brachytherapy ERT 3D-HDR-BT versus conventional external beam radiotherapy ERT for the treatment of stage T2b nasopharyngeal carcinoma NPC . Methods Forty NPC patients diagnosed with stage T2b NPC were treated with ERT 3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period. Results Patients treated with ERT 3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate vs. P and disease-free survival rate vs. P . Using multivariate analysis administration of 3D-HDR-BT was found to be favorable for local control P and was statistically significant for disease-free survival P . The incidence rate of acute and chronic complications between the two groups was also compared. Conclusions It is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied. Introduction In 1996 Chua et al. 1 reported the incidence of parapharyngeal extension in NPC patients to be as high as . Of these patients exhibited extensions into the prestyloid space and or the masticator space which was associated with lower rates of 5-year local control and distant metastasis-free survival. Numerous studies also showed that parapharyngeal extension was an unfavorable prognosis factor in predicting overall relapse local