tailieunhanh - Báo cáo y học: "Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. | Available online http content 8 6 223 Review Antibody-induced arthritis disease mechanisms and genes involved at the effector phase of arthritis Kutty Selva Nandakumar and Rikard Holmdahl Medical Inflammation Research Lund University Lund 22184 Sweden Corresponding author Kutty Selva Nandakumar nan@ Published 11 January 2007 This article is online at http content 8 6 223 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 223 doi ar2089 Abstract During the development of rheumatoid arthritis RA autoantibodies to IgG-Fc citrullinated proteins collagen type II CII glucose 6 phosphoisomerase G6PI and some other self-antigens appear. Of these a pathogenic effect of the anti-CII and anti-G6PI antibodies is well demonstrated using animal models. These new antibody mediated arthritis models have proven to be very useful for studies involved in understanding the molecular pathways of the induction of arthritis in joints. Both the complement and FcyR systems have been found to play essential roles. Neutrophils and macrophages are important inflammatory cells and the secretion of tumour necrosis factor-a and IL-1 p is pathogenic. The identification of the genetic polymorphisms predisposing to arthritis is important for understanding the complexity of arthritis. Disease mechanisms and gene regions studied using the two antibody-induced arthritis mouse models collagen antibody-induced arthritis and serum transfer-induced arthritis are compared and discussed for their relevance in RA pathogenesis. Introduction Both genetic and environmental factors interact and contribute to the development of autoimmune diseases. One such disease debilitating joint architecture is rheumatoid arthritis RA . Arthritis in the joint involves a multicellular inflammatory process including infiltration of lymphocytes and granulocytes into the articular cartilage proliferation of synovial fibroblasts and macrophages and .

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