tailieunhanh - Báo cáo khoa học: "Chemo-radiation with or without mandatory split in anal carcinoma: experiences of two institutions and review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Chemo-radiation with or without mandatory split in anal carcinoma: experiences of two institutions and review of the literature. | Oehler et al. Radiation Oncology 2010 5 36 http content 5 1 36 RADIATION ONCOLOGY RESEARCH Open Access Chemo-radiation with or without mandatory split in anal carcinoma experiences of two institutions and review of the literature Christoph Oehler 41 Sawyna Provencher42 David Donath3 Jean-Paul Bahary3 Urs M Lutolf 1 and I Frank Ciernik4 5 Abstract Background The split-course schedule of chemo-radiation for anal cancer is controversial. Methods Eighty-four patients with invasive anal cancer treated with definitive external beam radiotherapy RT with a mandatory split of 12 days 52 patients Montreal Canada or without an intended split 32 patients Zurich Switzerland were reviewed. Total RT doses were 52 Gy Montreal or Gy Zurich given concurrently with 5-FU MMC. Results After a mean follow-up of 40 27 months overall survival and local tumor control at 5 years were 57 and 78 Zurich compared to 67 and 82 Montreal respectively. Split duration of patients with or without local relapse was 15 7 d vs. 14 7 d Montreal NS and 11 11 d vs. 5 7 d Zurich P . Patients from Zurich with prolonged treatment interruption 7 d had impaired cancer-specific survival compared with patients with only minor interruption 7 d P . Bowel toxicity was associated with prolonged RT P duration as well as increased relapse probability P . Skin toxicity correlated with institution and was found in 79 Montreal and 28 Zurich P . Conclusions The study design did not allow demonstrating a clear difference in efficacy between the treatment regimens with or without short mandatory split. Cause-specific outcome appears to be impaired by unplanned prolonged interruption. Introduction Sphincter-sparing radiotherapy RT alone or chemoradiation CRT with fluorouracil 5-FU and mitomycin-C MMC is the standard of care for curative treatment of squamous cell carcinoma of the anal canal 1-5 . The Radiation Therapy Oncology Group RTOG experience with chemoradiation for .