tailieunhanh - Báo cáo khoa học: " Radiotherapy of large target volumes in Hodgkin's lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Radiotherapy of large target volumes in Hodgkin's lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques. | Cella etal. Radiation Oncology 2010 5 33 http content 5 1 33 RADIATION ONCOLOGY RESEARCH Open Access Radiotherapy of large target volumes in Hodgkin s lymphoma normal tissue sparing capability of forward IMRT versus conventional techniques Laura Cella 1 2 Raffaele Liuzzi1 2 Mario Magliulo1 Manuel Conson2 Luigi Camera2 Marco Salvatore2 and Roberto Pacelli 1 2 Abstract Background This paper analyses normal tissue sparing capability of radiation treatment techniques in Hodgkin s lymphoma with large treatment volume. Methods 10 patients with supradiaphragmatic Hodgkin s lymphoma and planning target volume PTV larger than 900 cm3 were evaluated. Two plans were simulated for each patient using 6 MV X-rays a conventional multi-leaf MLC parallel-opposed AP-PA plan and the same plan with additional MLC shaped segments forward planned intensity modulated radiation therapy FPIMRT . In order to compare plans dose-volume histograms DVHs of PTV lungs heart spinal cord breast and thyroid were analyzed. The Inhomogeneity Coefficient IC the PTV receiving 95 of the prescription dose V95 the normal tissue complication probability NTCP and dose-volume parameters for the OARs were determined. Results the PTV coverage was improved mean V95AP-PA and ICAP-PA vs. V95FPIMRT and ICFPIMRT p by the FPIMRT technique compared to the conventional one. At the same time NTCPs of lung spinal cord and thyroid and the volume of lung and thyroid receiving 30 Gy resulted significantly reduced when using the FPIMRT technique. Conclusions The FPIMRT technique can represent a very useful and at the same time simple method for improving PTV conformity while saving critical organs when large fields are needed as in Hodgkin s lymphoma. Background Radiation treatment and antiblastic chemotherapy of Hodgkin s lymphoma HL is a proven curative therapeutic strategy capable of curing the vast majority of patients. Radiotherapy in Hodgkin s lymphoma is very often .