tailieunhanh - Báo cáo khoa học: "Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients. | Scorsetti et al. Radiation Oncology 2010 5 93 http content 5 1 93 RADIATION ONCOLOGY RESEARCH Open Access Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients 1 2 1 1 1 1 Marta Scorsetti Antonella Fogliata Simona Castiglioni Caterina Bressi Mario Bignardi Piera Navarria 1 I z- -2 1 1 1 Pietro Mancosu Luca Cozzi Sara Pentimalli Filippo Alongi Armando Santoro Abstract Background To report about early clinical experience in radiation treatment of head and neck cancer of different sites and histology by volumetric modulated arcs with the RapidArc technology. Methods During 2009 45 patients were treated at Istituto Clinico Humanitas with RapidArc 28 males and 17 females median age 65 years . Of these 78 received concomitant chemotherapy. Thirty-six patients were treated as exclusive curative intent group A three as postoperative curative intent group B and six with sinonasal tumours group C . Dose prescription was at Planning Target Volumes PTV with simultaneous integrated boost and in 33 fractions group A and 66Gy in 33 fractions group B and 55Gy in 25 fractions group C . Results Concerning planning optimization strategies and constraints as per PTV coverage for all groups D98 95 and V95 99 . As regards organs at risk all planning objectives were respected and this was correlated with observed acute toxicity rates. Only 28 of patients experienced G3 mucositis 14 G3 dermitis 44 had G2 dysphagia. Nobody required feeding tubes to be placed during treatment. Acute toxicity is also related to chemotherapy. Two patients interrupted the course of radiotherapy because of a quick worsening of general clinical condition. Conclusions These preliminary results stated that volumetric modulated arc therapy in locally advanced head and neck cancers is feasible and effective with acceptable toxicities. Introduction Radiotherapy RT with or without chemotherapy is the primary treatment modality for .