tailieunhanh - Báo cáo khoa học: "Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensitymodulated radiation therapy (IMRT) in anal canal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensitymodulated radiation therapy (IMRT) in anal canal cancer. | Vieillot et al. Radiation Oncology 2010 5 92 http content 5 1 92 RADIATION ONCOLOGY RESEARCH Open Access Plan comparison of volumetric-modulated arc therapy RapidArc and conventional intensity-modulated radiation therapy IMRT in anal canal cancer 11 1 1 2 1 Sabine Vieillot David Azria Claire Lemanski Carmen Llacer Moscardo Sophie Gourgou Jean-Bernard Dubois Norbert Aillères1 Pascal Fenoglietto1 Abstract Background To compare volumetric-modulated arc therapy RapidArc plans with conventional intensity-modulated radiation therapy IMRT plans in anal canal cancers. Methods Ten patients with anal canal carcinoma previously treated with IMRT in our institution were selected for this study. For each patient three plans were generated with the planning CT scan one using a fixed beam IMRT and two plans using the RapidArc technique a single RA1 and a double RA2 modulated arc therapy. The treatment plan was designed to deliver in one process with simultaneous integrated boost SIB a dose of Gy to the planning target volume PTV2 based on the gross disease in a Gy-daily fraction 5 days a week. At the same time the subclinical disease PTV1 was planned to receive Gy in a Gy-daily fraction. Plans were normalized to 99 of the PTV2 that received 95 of the prescribed dose. Planning objectives were 95 of the PTV1 will receive 95 of the prescribed dose and no more than 2 of the PTV will receive more than 107 . Dosevolume histograms DVH for the target volume and the organs at risk bowel tract bladder iliac crests femoral heads genitalia perineum and healthy tissue were compared for these different techniques. Monitor units MU and delivery treatment time were also reported. Results All plans achieved fulfilled objectives. Both IMRT and RA2 resulted in superior coverage of PTV than RA1 that was slightly inferior for conformity and homogeneity p . Conformity index CI95 for the PTV2 was RA2 IMRT and RA1 . Homogeneity D5 -