tailieunhanh - Báo cáo khoa học: "Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan. | Chang et al. Radiation Oncology 2010 5 91 http content 5 1 91 RADIATION ONCOLOGY RESEARCH Open Access Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan Morgan Fu-Ti Chang1 Hung-Ming Wang2 5 6 Chung-Jan Kang3 5 Shiang-Fu Huang3 5 Chien-Yu Lin4 5 7 Kang-Hsing Fang4 5 7 Eric Yen-Chao Chen4 5 I-How Chen3 5 Chun-Ta Liao3 5 Joseph Tung-Chieh Chang4 5 6 Abstract Purpose The aim of this study was to evaluate treatment results in our hypopharyngeal cancer patients. Patients and Methods A total of three hundred and ninety five hypopharyngeal cancer patients received radical treatment at our hospital 96 were male. The majority were habitual smokers 88 alcohol drinkers 73 and or betel quid chewers 51 . All patients received a CT scan or MRI for tumor staging before treatment. The stage distribution was stage I 2 stage II 22 stage III 57 and stage IV 314 . Radical surgery was used first in 81 patients and the remaining patients received organ preservation-intended treatment OPIT . In the OPIT group 46 patients received radiotherapy alone 156 patients received chemotherapy followed by radiotherapy CT RT and 112 patients received concomitant chemo-radiotherapy CCRT . Results The five-year overall survival rates for stages I II III and IV were and respectively. There was no significant difference in overall and disease-specific survival rates between patients who received radical surgery first and those who received OPIT. In the OPIT group CCRT tended to preserve the larynx better p with three-year larynx preservation rates of for CCRT and for CT RT. Thirty-seven patients developed a second malignancy with an annual incidence of . Conclusions There was no survival difference between OPIT and radical surgery in hypopharyngeal cancer patients at our hospital. CCRT may offer better laryngeal preservation than RT alone or CT .