tailieunhanh - Báo cáo khoa học: "Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature. | Jingu et al. Radiation Oncology 2010 5 89 http content 5 1 89 RADIATION ONCOLOGY CASE REPORT Open Access Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck preliminary report of six cases and review of the literature Keiichi Jingu Azusa Hasegawa Jun-Etsu Mizo Hiroki Bessho Takamichi Morikawa Hiroshi Tsuji Hirohiko Tsujii Tadashi Kamada Abstract Background Basal cell adenocarcinoma accounts for approximately of all salivary gland neoplasms. In this report we describe our experiences of treatment for BCAC with carbon ion radiotherapy in our institution. Methods Case records of 6 patients with diagnosis of basal cell adenocarcinoma of the head and neck who were treated by carbon ion radiotherapy with GyE 16 fractions in our institution were retrospectively reviewed. Results In a mean follow-up period of months months overall survival and local control rates of 100 were achieved. Only one grade 4 CTCAE late complication occurred. There was no other grade 3 or higher toxicity. Conclusions Carbon ion radiotherapy should be considered as an appropriate curative approach for treatment of basal cell adenocarcinoma in certain cases particularly in cases of unresectable disease and postoperative gross residual or recurrent disease. Background Basal cell adenocarcinoma BCAC was first recognized in 1978 and accounts for approximately of all salivary gland neoplasms 1 . BCAC typically arises in adults older than 60 years of age and has no gender predominance 2 . The vast majority of BCACs occur in the parotid gland about 90 3-5 followed by the submandibular gland and minor salivary glands 6 . The 2005 WHO classification categorizes BCAC as a low-grade tumor with a favorable prognosis 7 . The standard treatment has been wide local excision with or without postoperative radiotherapy. However local recurrence has frequently been reported. Carbon ion radiation therapy C-ion RT was initiated at the National .