tailieunhanh - Báo cáo khoa học: "Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. | Chitapanarux et al. Radiation Oncology 2010 5 31 http content 5 1 31 RADIATION ONCOLOGY RESEARCH Open Access Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients Imjai Chitapanarux 1 Taned Chitapanarux2 Patrinee Traisathit3 Sudkaneung Kudumpee1 Ekkasit Tharavichitkul1 and Vicharn Lorvidhaya1 Abstract Background Radiation-induced diarrhea is frequently observed during pelvic radiotherapy. This study was performed to determine the ability of a probiotic containing live lactobacillus acidophilus plus bifidobacterium bifidum to reduce the incidence of radiation-induced diarrhea in locally advanced cervical cancer patients. Methods Patients who were undergoing pelvic radiotherapy concurrent with weekly cisplatin were randomly assigned to a study drug or placebo in a double-blind study. Diarrhea was graded weekly according the Common Toxicity Criteria CTC system. Stool consistency and white and red blood cell count in stool were also assessed. The primary endpoint was to reduce the incidence of diarrhea defined by a CTC grade 2 or more and the need for anti-diarrheal medication. Results A total of 63 patients were enrolled. Grade 2 -3 diarrhea was observed in 45 of the placebo group n 31 and 9 of the study drug group n 32 p . Anti-diarrheal medication use was significantly reduced in the placebo group p . The patients in the study drug group had a significantly improved stool consistency p . Conclusions Live lactobacillus acidophilus plus bifidobacterium bifidum reduced the incidence of radiation-induced diarrhea and the need for anti-diarrheal medication and had a significant benefits on stool consistency. Background Radical radiation therapy to pelvic malignancy carries a risk of complications to normal tissues around the tumor. Acute complications affecting the gastrointestinal tract occur in approximately 80 of patients