tailieunhanh - Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What is MRI bone oedema in rheumatoid arthritis and why does it matter? | Available online http content 8 6 222 Review What is MRI bone oedema in rheumatoid arthritis and why does it matter Fiona M McQueen1 and Benedikt Ostendorf2 1 Department of Molecular Medicine and Pathology Faculty of Medicine and Health Sciences University of Auckland Park Rd Auckland New Zealand 2Center for Rheumatology Department of Endocrinology Diabetology and Rheumatology Heinrich-Heine University Dusseldorf Dusseldorf Germany Corresponding author Fiona M McQueen Published 5 December 2006 This article is online at http content 8 6 222 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 222 doi ar2075 Abstract MRI bone oedema occurs in various forms of inflammatory and noninflammatory arthritis and probably represents a cellular infiltrate within bone. It is common in early rheumatoid arthritis and is associated with erosive progression and poor functional outcome. Histopathological studies suggest that a cellular infiltrate comprising lymphocytes and osteoclasts may be detected in subchondral bone and could mediate the development of erosions from the marrow towards the joint surface. There is emerging evidence from animal models that such an infiltrate corresponds with MRI bone oedema pointing towards the bone marrow as a site for important pathology driving joint damage in rheumatoid arthritis. In the mid-17th century a Dutch apprentice to a textile merchant Anton van Leeuwenhoek was the first to see and describe bacteria yeasts and the circulation of blood corpuscles in capillaries using a new tool the light microscope 1 . The subsequent elucidation of the microbiological basis of infectious disease can be traced back in part to his pioneering work in imaging. A parallel exists between the invention of the microscope and the development of magnetic resonance imaging MRI which allows new ways to explore biological systems. In rheumatoid arthritis RA MRI provides information