tailieunhanh - Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice. | Available online http content 8 4 R93 Research article Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice Alexei von Delwig1 Catharien MU Hilkens1 Daniel M Altmann2 Rikard Holmdahl3 John D Isaacs1 Clifford V Harding4 Helen Robertson5 Norman McKie1 and John H Robinson1 1Musculoskeletal Research Group Clinical Medical Sciences University of Newcastle upon Tyne Framlington Place Newcastle upon Tyne UK 2Human Disease Immunogenetics Group Department of Infectious Diseases Imperial College School of Medicine Hammersmith Hospital London UK department of Cell and Molecular Biology Lund University Lund Sweden department of Pathology Case Western Reserve University Cleveland OH USA 5BioImaging Facility Clinical Laboratory Sciences University of Newcastle upon Tyne Framlington Place Newcastle upon Tyne UK Corresponding author Alexei von Delwig Received 16 Feb 2006 Revisions requested 27 Mar 2006 Revisions received 13 Apr 2006 Accepted 24 Apr 2006 Published 16 May 2006 Arthritis Research Therapy 2006 8 R93 doi ar1964 This article is online at http content 8 4 R93 2006 von Delwig et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Professional antigen-presenting cells such as dendritic cells macrophages and B cells have been implicated in the pathogenesis of rheumatoid arthritis constituting a possible target for antigen-specific immunotherapy. We addressed the possibility of blocking antigen presentation of the type II collagen CII -derived immunodominant arthritogenic epitope CII259_273 to specific CD4 T cells by inhibition of antigen uptake in .