tailieunhanh - Báo cáo khoa học: "Consequential late effects after radiotherapy for prostate cancer - a prospective longitudinal quality of life study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Consequential late effects after radiotherapy for prostate cancer - a prospective longitudinal quality of life study. | Pinkawa et al. Radiation Oncology 2010 5 27 http content 5 1 27 RADIATION ONCOLOGY RESEARCH Open Access Consequential late effects after radiotherapy for prostate cancer - a prospective longitudinal quality of life study Michael Pinkawa Richard Holy Marc D Piroth Karin Fischedick Sandra Schaar Dalma Székely-Orbán Michael J Eble Abstract Background To answer the question if and to which extent acute symptoms at the end and or several weeks after radiotherapy can predict adverse urinary and gastrointestinal long-term quality of life QoL . Methods A group of 298 patients has been surveyed prospectively before time A at the last day B two months after C and one year after D radiotherapy using a validated questionnaire Expanded Prostate Cancer Index Composite . A subgroup of 10 with the greatest urinary bowel bother score decrease at time D was defined as patients with adverse long-term QoL. Results Subgroup and correlation analyses could demonstrate a strong dependence of urinary bowel QoL after radiotherapy on urinary bowel QoL before radiotherapy. In contrast to absolute scores QoL score changes relative to baseline scores did not correlate with pretreatment scores. Long-term changes could be well predicted by acute changes. Patients reporting great moderate bother with urinary bowel problems at time C reported to have great moderate bother at time D in 50 respectively. In a multivariate analysis of factors for adverse long-term urinary and bowel QoL score changes at time C were found to be independent predictors respectively. Additionally QoL changes at time B were independently predictive for adverse long-term bowel QoL. Conclusions Consequential late effects play a major role after radiotherapy for prostate cancer. Patients with greater and particularly longer non-healing acute toxicity are candidates for closer follow-up and possible prophylactic actions to reduce a high probability of long-term problems. Background External beam radiotherapy .