tailieunhanh - Báo cáo khoa học: "Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy. | Kuo et al. Radiation Oncology 2011 6 76 http content 6 1 76 RADIATION ONCOLOGY RESEARCH Open Access Volumetric intensity-modulated Arc RapidArc therapy for primary hepatocellular carcinoma comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy Yu-Cheng Kuo1 2 4 Ying-Ming Chiu5 Wen-Pin Shih2 Hsiao-Wei Yu6 Chia-Wen Chen3 Pei-Fong Wong7 Wei-Chan Lin 1 and Jeng-Jong Hwang1 Abstract Background To compare the RapidArc plan for primary hepatocellular carcinoma HCC with 3-D conformal radiotherapy 3DCRT and intensity-modulated radiotherapy IMRT plans using dosimetric analysis. Methods Nine patients with unresectable HCC were enrolled in this study. Dosimetric values for RapidArc IMRT and 3DCRT were calculated for total doses of45 Gy using Gy day. The parameters included the conformal index CI homogeneity index HI and hot spot V107 for the planned target volume PTV as well as the monitor units MUs for plan efficiency the mean dose Dmean for the organs at risk OAR and the maximal dose at 1 volume D1 for the spinal cord. The percentage of the normal liver volume receiving 40 30 20 and 10 Gy V40 Gy V30 Gy V20 Gy and V10 Gy and the normal tissue complication probability NTCP were also evaluated to determine liver toxicity. Results All three methods achieved comparable homogeneity for the PTV. RapidArc achieved significantly better CI and V107 values than IMRT or 3DCRT p . The MUs were significantly lower for RapidArc and 3DCRT than for IMRT p . IMRT achieved a significantly lower Dmean of the normal liver than did 3DCRT or RapidArc p . 3DCRT had higher V40 Gy and V30 Gy values for the normal liver than did RapidArc or IMRT. Although the V10 Gy to the normal liver was higher with RapidArc than with 3DCRT or IMRT and respectively p the NTCP did not differ significantly between RapidArc and IMRT and both were better than .

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