tailieunhanh - Báo cáo y học: "Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics. | Available online http content 8 6 R165 Research article Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal fibrotic characteristics Marjan MC Steenvoorden1 2 Tanja CA Tolboom1 Gabri van der Pluijm3 Clemens Lowik3 Cornelis PJ Visser4 Jeroen DeGroot2 Adriana C Gittenberger-DeGroot5 Marco C DeRuiter5 Bert J Wisse5 Tom WJ Huizinga1 and René EM Toes1 Department of Rheumatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden The Netherlands 2TNO Quality of Life Business Unit Biomedical Research Zernikedreef 9 2333 CK Leiden The Netherlands department of Endocrinology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden The Netherlands department of Orthopaedics Rijnland Hospital Simon Smitweg 1 2353 GA Leiderdorp The Netherlands department of Anatomy and Embryology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden The Netherlands Corresponding author René EM Toes Received 4 Jul 2006 Revisions requested 9 Aug 2006 Revisions received 28 Sep 2006 Accepted 31 Oct 2006 Published 31 Oct 2006 Arthritis Research Therapy 2006 8 R165 doi ar2073 This article is online at http content 8 6 R165 2006 Steenvoorden et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The healthy synovial lining layer consists of a single cell layer that regulates the transport between the joint cavity and the surrounding tissue. It has been suggested that abnormalities such as somatic mutations in the p53 tumor-suppressor gene contribute to synovial hyperplasia and invasion in rheumatoid arthritis RA . In this study expression of epithelial markers on healthy and .