tailieunhanh - Báo cáo khoa học: "Intensity modulated radiotherapy for elderly bladder cancer patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Intensity modulated radiotherapy for elderly bladder cancer patients. | Hsieh et al. Radiation Oncology 2011 6 75 http content 6 1 75 RADIATION ONCOLOGY RESEARCH Open Access Intensity modulated radiotherapy for elderly bladder cancer patients 2 22 2 3 Chen-Hsi Hsieh 1 Shiu-Dong Chung Pei-Hui Chan Siu-Kai Lai Hsiao-Chun Chang Chi-Huang Hsiao Le-Jung Wu1 Ngot-Swan Chong1 Yu-Jen Chen4 5 7 8 Li-Ying Wang9 Yen-Ping Hsieh10 and Pei-Wei Shueng1 6 Abstract Background To review our experience and evaluate treatment planning using intensity-modulated radiotherapy IMRT and helical tomotherapy HT for the treatment of elderly patients with bladder cancer. Methods From November 2006 through November 2009 we enrolled 19 elderly patients with histologically confirmed bladder cancer 9 in the IMRT and 10 in the HT group. The patients received Gy to the bladder with or without concurrent chemotherapy. Conventional 4-field box pelvic radiation therapy 2DRT plans were generated for comparison. Results The median patient age was 80 years old range 65-90 years old . The median survival was 21 months 5 to 26 months . The actuarial 2-year overall survival OS for the IMRT vs. the HT group was vs . respectively the corresponding values for disease-free survival were vs. respectively for locoregional progression-free survival LRPFS the values were vs. respectively and for metastases-free survival the values were vs. respectively. The 2-year OS rates for T1 2 vs. T3 4 were vs. respectively p . The 2-year OS rate was poor for those whose RT completion time greater than 8 weeks when compared with the RT completed within 8 wks vs. 0 p . Conclusion IMRT and HT provide good LRPFS with tolerable toxicity for elderly patients with invasive bladder cancer. IMRT and HT dosimetry and organ sparing capability were superior to that of 2DRT and HT provides better sparing ability than IMRT. The T category and the RT completion time influence OS rate. Keywords Bladder cancer Concurrent