tailieunhanh - Báo cáo khoa học: "Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer. | Schmitz et al. Radiation Oncology 2010 5 80 http content 5 1 80 RADIATION ONCOLOGY RESEARCH Open Access Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer I V 11 h o A D Cch m i1 71 t I hprt n A Pa rJi ilo2 3t Potrick V c hiin1t Alpn T Pl o ic4 5 t Matthew D Scillliuz Gilbert JA radula rdtlick I dun Alan I Davis Abstract Background The purpose of this study was to determine the expected time to prostate specific antigen PSA normalization with or without neoadjuvant androgen deprivation NAAD therapy after treatment with intensity modulated radiotherapy IMRT for patients with clinically localized prostate cancer. Methods A retrospective cohort research design was used. A total of 133 patients with clinical stage T1c to T3b prostate cancer 2002 AJCC staging treated in a community setting between January 2002 and July 2005 were reviewed for time to PSA normalization using 1 ng mL and 2 ng mL as criteria. All patients received IMRT as part of their management. Times to PSA normalization were calculated using the Kaplan-Meier method. Significance was assessed at p . Results Fifty-six of the 133 patients received NAAD . Thirty-one patients received radiation to a limited pelvic field followed by an IMRT boost while 99 patients received IMRT alone . The times to serum PSA normalization 2 ng mL when treated with or without NAAD were 298 24 and 302 33 days mean SEM respectively p and 303 24 and 405 46 days respectively for PSA 1 ng mL p . Stage T1 and T2 tumors had significantly increased time to PSA normalization 1 ng mL in comparison to Stage T3 tumors. Also higher Gleason scores were significantly correlated with a faster time to PSA normalization 1 ng mL. Conclusions Use of NAAD in conjunction with IMRT leads to a significantly shortened time to normalization of serum PSA 1 ng mL in patients with clinically localized prostate cancer.