tailieunhanh - Báo cáo khoa học: "Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets. | Wolff et al. Radiation Oncology 2010 5 77 http content 5 1 77 RADIATION ONCOLOGY RESEARCH Open Access Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets Hendrik A Wolff Daniela M Wagner Hans Christiansen Clemens F Hess Hilke Vorwerk Abstract Background Stereotactic-Radio-Surgery SRS using Conformal-Arc-Therapy CAT is a well established irradiation technique for treatment of intracranial targets. Although small safety margins are required because of very high accuracy of patient positioning and exact online localisation there are still disadvantages like long treatment time high number of monitor units MU and covering of noncircular targets. This planning study analysed whether Rapid Arc RA with stereotactic localisation for single-fraction SRS can solve these problems. Methods Ten consecutive patients were treated with Linac-based SRS. Eight patients had one or more brain metastases. The other patients presented a symptomatic vestibularis schwannoma and an atypic meningeoma. For all patients two plans CAT RA were calculated and analysed. Results Conformity was higher for RA with additional larger low-dose areas. Furthermore RA reduced the number of MU and the treatment time for all patients. Dose to organs at risk were equal or slightly higher using RA in comparison to CAT. Conclusions RA provides a new alternative for single-fraction SRS irradiation combining advantages of short treatment time with lower number of MU and better conformity in addition to accuracy of stereotactic localisation in selected cases with uncomplicated clinical realization. Background Stereotactic Radiosurgery SRS using Conformal Arc Therapy CAT is a well established and commonly used irradiation technique for applying high dose to the target while sparing dose to surrounding critical structures via steep dose gradient outside the lesion 1 2 . A very high accuracy of patient positioning and exact online localisation during treatment is .