tailieunhanh - Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus. | Available online http content 8 3 R81 Research article Activation of transforming growth factor-31 and early atherosclerosis in systemic lupus erythematosus Michelle Jackson1 Yasmeen Ahmad2 Ian N Bruce2 Beatrice Coupes1 and Paul EC Brenchley1 1Renal Research Laboratories Manchester Institute of Nephrology and Transplantation Manchester Royal Infirmary Manchester UK 2University of Manchester Rheumatism Research Centre Central Manchester and Manchester Children s University NHS Trust Manchester Royal Infirmary Manchester UK Corresponding author Paul EC Brenchley Received 21 Oct 2005 Revisions requested 21 Dec 2005 Revisions received 21 Mar 2006 Accepted 31 Mar 2006 Published 28 Apr 2006 Arthritis Research Therapy 2006 8 R81 doi ar1 951 This article is online at http content 8 3 R81 2006 Jackson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The efficiency of activating latent transforming growth factor TGF -Pi in systemic lupus erythematosus SLE may control the balance between inflammation and fibrosis modulating the disease phenotype. To test this hypothesis we studied the ability to activate TGF-Pi in SLE patients and control individuals within the context of inflammatory disease activity cumulative organ damage and early atherosclerosis. An Activation Index AI for TGF-P1 was determined for 32 patients with SLE and 33 age-matched and sex-matched control individuals by quantifying the increase in active TGF-P1 under controlled standard conditions. Apoptosis in peripheral blood mononuclear cells was determined by fluorescence-activated cell sorting. Carotid artery intima-media thickness was measured using .