tailieunhanh - Báo cáo y học: "Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. | Available online http content 8 3 R79 Research article Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis Laetitia Michou1 Pascal Croiseau2 Elisabeth Petit-Teixeira1 Sophie Tezenas du Montcel2 3 Isabelle Lemaire1 4 Céline Pierlot1 José Osorio1 Wafa Frigui1 Sandra Lasbleiz1 5 Patrick Quillet1 4 Thomas Bardin1 5 Bernard Prum6 Frangoise Clerget-Darpoux2 Frangois Cornélis1 5 7 and the European Consortium on Rheumatoid Arthritis Families 1GenHotel-EA 3886 University Evry-ParisVII Medical School Member of the Autocure European Consortium Evry-Genopole France 2INSERM U 535 University Paris XI Villejuif France 3Service de Biostatistiques et d Information Médicale CHU Pitié-Salpétrière Assistance Publique-Hôpitaux de Paris Paris France 4Laboratoire de Biologie Centre Hospitalier Sud Francilien Corbeil-Essonne France 5Unité de Génétique Clinique Adulte Hôpital Lariboisière Assistance Publique-Hôpitaux de Paris Paris France 6Laboratoire Statistique et Génome Evry-Genopole France 7Consultation de Génétique Adulte Centre Hospitalier Sud Francilien Evry-Corbeil France Corresponding author Laetitia Michou michou@ Received 7 Feb 2006 Revisions requested 10 Mar 2006 Revisions received 26 Mar 2006 Accepted 29 Mar 2006 Published 28 Apr 2006 Arthritis Research Therapy 2006 8 R79 doi ar1 949 This article is online at http content 8 3 R79 2006 Michou et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Recently we proposed a classification of HLA-DRB1 alleles that reshapes the shared epitope hypothesis in rheumatoid arthritis RA according to this model RA is associated with the RAA shared epitope sequence 72-74 .