tailieunhanh - Báo cáo y học: "Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma. | Available online http content 8 6 R161 Research article Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma Tsuyoshi Iwasaki1 Takehito Imado2 Sachie Kitano1 and Hajime Sano1 Division of Rheumatology and Clinical Immunology Department of Internal Medicine Hyogo College of Medicine 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 Japan 2Division of Hematology Department of Internal Medicine Hyogo College of Medicine 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 Japan Corresponding author Tsuyoshi Iwasaki tsuyo-i@ Received 2 May 2006 Revisions requested 20 Jun 2006 Revisions received 14 Sep 2006 Accepted 18 Oct 2006 Published 18 Oct 2006 Arthritis Research Therapy 2006 8 R161 doi ar2068 This article is online at http content 8 6 R161 2006 Iwasaki et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The tight-skin TSK mouse a genetic model of systemic sclerosis SSc develops cutaneous fibrosis and defects in pulmonary architecture. Because hepatocyte growth factor HGF is an important mitogen and morphogen that contributes to the repair process after tissue injury we investigated the role of HGF in cutaneous fibrosis and pulmonary architecture defects in SSc using TSK mice. TSK mice were injected in the gluteal muscle with either hemagglutinating virus of Japan HVJ liposomes containing 8 of a human HGF expression vector HGF-HVJ liposomes or a mock vector untreated control . Gene transfer was repeated once weekly for 8 weeks. The effects of HGF gene transfection on the histopathology and expression of tumor growth factor TGF -p and IL-4 mRNA in TSK mice were examined. The effect of recombinant HGF .