tailieunhanh - Báo cáo y học: "Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis. | Available online http content 8 6 R160 Research article Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional clinical and radiological signs of lung fibrosis AM Fietta1 4 AM Bardoni2 R Salvini2 I Passadore1 M Morosini1 L Cavagna3 4 V Codullo3 4 E Pozzi1 4 F Meloni1 4 and C Montecucco3 4 Open Access Department of Haematological Pneumological and Cardiovascular Sciences University of Pavia Via Taramelli 5 27100 Pavia Italy department of Biochemistry University of Pavia Via Taramelli 5 27100 Pavia Italy department of Internal Medicine University of Pavia Via Taramelli 5 27100 Pavia Italy 4IRCCS San Matteo Piazzale Golgi 2 27100 Pavia Italy Corresponding author AM Fietta Received 7 Mar 2006 Revisions requested 21 Apr 2006 Revisions received 31 May 2006 Accepted 17 Oct 2006 Published 17 Oct 2006 Arthritis Research Therapy 2006 8 R160 doi ar2067 This article is online at http content 8 6 R160 2006 Fietta et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Lung fibrosis is a major cause of mortality and morbidity in systemic sclerosis SSc . However its pathogenesis still needs to be elucidated. We examined whether the alteration of certain proteins in bronchoalveolar lavage fluid BALF might have a protective or a causative role in the lung fibrogenesis process. For this purpose we compared the BALF protein profile obtained from nine SSc patients with lung fibrosis SScFib with that obtained from six SSc patients without pulmonary fibrosis SScFib- by two-dimensional gel electrophoresis 2-DE . Only spots and spot-trains that were consistently expressed in a different way in the two study .

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