tailieunhanh - Báo cáo khoa học: "Validation of bidimensional measurement in nasopharyngeal carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Validation of bidimensional measurement in nasopharyngeal carcinoma. | Chang et al. Radiation Oncology 2010 5 72 http content 5 1 72 RADIATION ONCOLOGY RESEARCH Open Access Validation of bidimensional measurement in nasopharyngeal carcinoma 111 1 1 2 3 Ting-Shou Chang Sau-Tung Chu Yu-Yi Hou Kuo-Ping Chang Chao-Chuan Chi Ching-Chih Lee Abstract Background Our previous study showed a close relationship between computed tomography CT -derived bidimensional measurement of primary tumor and retropharyngeal nodes BDMprn and gross tumor volume of primary tumor and retropharyngeal nodes GTVprn in nasopharyngeal carcinoma NPC and better prognosis for NPC patients with smaller BDMprn. In this study we report the results on of a study to validate the use of BDM in a separate cohort of NPC patients. Methods We retrospectively reviewed 103 newly diagnosed NPC cases who were treated with radiotherapy concurrent chemoradiotherapy CCRT or CCRT with adjuvant chemotherapy from 2002 to 2009. We used magnetic resonance imaging MRI to measure BDMprn. We calculated overall survival recurrence-free and distant metastasis-free survival curves and set a BDMprn cut off point to categorize patients into a high- or low-risk group. We then used Cox proportional hazard model to evaluate the prognostic influence of BDMprn after correcting age gender and chemotherapy status. Results After adjusting for age gender and chemotherapy status BDMprn remained an independent prognostic factor for distant metastasis Hazard ratio HR P and overall survival HR P . Patients with BDMprn 15 cm 2 had a greater 3-year overall survival rate than those with BDMprn 15 cm2 vs. P . They also had a greater 3-year distant metastasis-free survival 94 P . Conclusion The predictive ability of BDMprn was validated in a separate NPC cohort. A BDMprn of 15 cm2 can be used to separate NPC patients into high- and low-risk groups and predict survival rates and metastasis potential. It can therefore be used as a reference to .