tailieunhanh - Báo cáo y học: "Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. | Available online http content 8 3 R77 Research article Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis Chrystal M Paulos1 Bindu Varghese1 William R Widmer2 Gert J Breur2 Erina Vlashi1 and Philip S Low1 1Department of Chemistry 560 Oval Drive 1393 Brown Bldg. Purdue University West Lafayette IN 47907-1175 USA 2Department of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette IN 47907-11 75 USA Contributed equally Corresponding author Philip S Low plow@ Received 5 Jan 2006 Revisions requested 7 Feb 2006 Revisions received 1 2 Mar 2006 Accepted 22 Mar 2006 Published 28 Apr 2006 Arthritis Research Therapy 2006 8 R77 doi ar1 944 This article is online at http content 8 3 R77 2006 Paulos et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Activated macrophages express a cell surface receptor for the vitamin folic acid. Because this receptor is inaccessible or not measurably expressed on other normal cells folic acid has been recently exploited to selectively deliver attached radio-emitters to sites of activated macrophage accumulation allowing scintigraphic imaging of inflamed joints and organs of arthritic rats. We demonstrate here that folate-linked haptens can also be targeted to activated macrophages decorating their cell surfaces with highly immunogenic molecules. Under conditions in which the rodent has already been immunized against keyhole limpet hemocyanine- fluorescein isothiocyanate FITC activated macrophages are eliminated. Administration of folate-FITC conjugates to rodents with experimental arthritis attenuates a systemic and .