tailieunhanh - Báo cáo khoa học: " Long-term outcome and patterns of failure in patients with advanced head and neck cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Long-term outcome and patterns of failure in patients with advanced head and neck cancer. | Hauswald et al. Radiation Oncology 2011 6 70 http content 6 1 70 RADIATION ONCOLOGY RESEARCH Open Access Long-term outcome and patterns of failure in patients with advanced head and neck cancer 1 2 1 1 1 Henrik Hauswald Christian Simon Simone Hecht Juergen Debus and Katja Lindel Abstract Purpose To access the long-time outcome and patterns of failure in patients with advanced head and neck squamous cell carcinoma HNSCC . Methods and materials Between 1992 and 2005 127 patients median age 55 years UICC stage III n 6 stage IV n 121 with primarily inoperable advanced HNSCC were treated with definite platinum-based radiochemotherapy median dose Gy . Analysed end-points were overall survival OS disease-free survival DFS loco-regional progression-free survival LPFS development of distant metastases DM prognostic factors and causes of death. Results The mean follow-up time was 34 months range 3-156 months the 3- 5- and 10-year OS rates were 39 28 and 14 respectively. The median OS was 23 months. Forty-seven patients achieved a complete remission and 78 patients a partial remission. The median LPFS was 17 months the 3- 5- and 10-year LPFS rates were 41 33 and 30 respectively. The LPFS was dependent on the nodal stage p . The median DFS was 11 months range 2-156 months the 3- 5- and 10-year DFS rates were 30 24 and 22 respectively. Prognostic factors in univariate analyses were alcohol abuse n 102 p complete remission n 47 p local recurrence n 71 p development of DM n 45 p median OS 16 months and borderline significance in nodal stage N2 versus N3 p . Median OS was 26 months with lung metastases n 17 . Nodal stage was a predictive factor for the development of DM p . Cause of death was most commonly tumor progression. Conclusions In stage IV HNSCC long-term survival is rare and DM is a significant predictor for mortality. If patients developed DM lung metastases had the most favourable prognosis so intensified