tailieunhanh - Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs. | Available online http content 8 3 R76 Research article Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs Haruko Ideguchi1 Shigeru Ohno1 Hideaki Hattori1 Akiko Senuma2 and Yoshiaki Ishigatsubo3 Open Access intractable Disease Center Yokohama City University Medical Center Yokohama Japan 2Department of Rheumatology Yokohama Minami Kyousai Hospital Yokohama Japan 3Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine Yokohama Japan Corresponding author Haruko Ideguchi ideguchi@ Received 9 Aug 2005 Revisions requested 14 Oct 2005 Revisions received 24 Feb 2006 Accepted 21 Mar 2006 Published 28 Apr 2006 Arthritis Research Therapy 2006 8 R76 doi ar1 943 This article is online at http content 8 3 R76 2006 Ideguchi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We conducted the present study to determine whether repair of erosions occurs in patients with rheumatoid arthritis RA treated with conventional disease-modifying anti-rheumatic drugs DMARDs and to compare clinical characteristics between patients exhibiting and not exhibiting erosion repair. We included in the study a total of 122 RA patients who fulfilled the 1987 American College of Rheumatology criteria for RA all patients had paired sequential radiographs of both hands and wrists showing erosive changes at baseline. Patients were classified into two groups according to the presence of repair of erosions at follow up namely the repair observed and repair not observed groups. Clinical characteristics disease activity radiographic scores