tailieunhanh - Báo cáo khoa học: "Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. | Moeller et al. Radiation Oncology 2011 6 58 http content 6 1 58 RADIATION ONCOLOGY RESEARCH Open Access Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy 1 2 1 113 Benjamin J Moeller Murali Chintagumpala Jimmy J Philip David R Grosshans Mary F McAleer Shiao Y Woo Paul W Gidley4 Tribhawan S Vats5 and Anita Mahajan1 Abstract Background Hearing loss is common following chemoradiotherapy for children with medulloblastoma. Compared to photons proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether this dosimetric advantage leads to a clinical benefit in audiometric outcomes. Methods From 2006-2009 23 children treated with proton radiotherapy for medulloblastoma were enrolled on a prospective observational study through which they underwent pre- and 1 year post-radiotherapy pure-tone audiometric testing. Ears with moderate to severe hearing loss prior to therapy were censored leaving 35 ears in 19 patients available for analysis. Results The predicted mean cochlear radiation dose was 30 60Co-Gy Equivalents range 19-43 and the mean cumulative cisplatin dose was 303 mg m2 range 298-330 . Hearing sensitivity significantly declined following radiotherapy across all frequencies analyzed P . There was partial sparing of mean post-radiation hearing thresholds at low-to-midrange frequencies and consequently the rate of high-grade grade 3 or 4 ototoxicity at 1 year was favorable 5 . Ototoxicity did not correlate with predicted dose to the auditory apparatus for proton-treated patients potentially reflecting a lower-limit threshold for radiation effect on the cochlea. Conclusions Rates of high-grade early post-radiation ototoxicity following proton radiotherapy for pediatric medulloblastoma are low. Preservation of hearing in the audible speech range as observed here may improve both quality of life and cognitive functioning for these patients. Keywords Proton .