tailieunhanh - Báo cáo khoa học: "SemiClinical application of tumor volume in advanced nasopharyngeal carcinoma to predict outcome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiClinical application of tumor volume in advanced nasopharyngeal carcinoma to predict outcome. | Lee et al. Radiation Oncology 2010 5 20 http content 5 1 20 RADIATION ONCOLOGY RESEARCH Open Access Clinical application of tumor volume in advanced nasopharyngeal carcinoma to predict outcome I z I I 1 5 I 7 J I I_Il I U z 2 ft l Z S. Z S. ụ- c I Z I J J 3 5 c I I_11 I nn I_I 1 I Z S. 1 I_I Z X t- Vì I I 3 5 w I I I J Cl I4 5 Ching-Chin Lee ize-id Huang Ivioon-sing Lee Shih-Hsuan Hsiao Hon-Ii Lin iu-cnien su Feng-Chun Hsu3 Shih-Kai Hung3 5 Abstract Background Current staging systems have limited ability to adjust optimal therapy in advanced nasopharyngeal carcinoma NPC . This study aimed to delineate the correlation between tumor volume treatment outcome and chemotherapy cycles in advanced NPC. Methods A retrospective review of 110 patients with stage III-IV NPC was performed. All patients were treated first with neoadjuvant chemotherapy then concurrent chemoradiation and followed by adjuvant chemotherapy as being the definitive therapy. Gross tumor volume of primary tumor plus retropharyngeal nodes GTVprn was calculated to be an index of treatment outcome. Results GTVprn had a close relationship with survival and recurrence in advanced NPC. Large GTVprn 13 ml was associated with a significantly poorer local control lower distant metastasis-free rate and poorer survival. In patients with GTVprn 13 ml overall survival was better after ễ4 cycles of chemotherapy than after less than 4 cycles. Conclusions The incorporation of GTVprn can provide more information to adjust treatment strategy. Background Nasopharyngeal carcinoma NPC is a unique malignant head and neck cancer with a specific behavior. It is rarely reported in the West but occurs at high frequency in Southern China Hong Kong Taiwan Singapore and Malaysia 1 . Radiotherapy has long been the standard treatment for patients with NPC because of its anatomic location and relative radiosensitivity. Based on the American Joint Committee on Cancer AJCC staging system in 1997 and the 5-year .