tailieunhanh - Báo cáo khoa học: "Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer. | Yasuda et al. Radiation Oncology 2011 6 49 http content 6 1 49 RADIATION ONCOLOGY RESEARCH Open Access Density of CD4 and CD8 T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy CRT for rectal cancer Koji Yasuda Takako Nirei Eiji Sunami Hirokazu Nagawa and Joji Kitayama Abstract Background Although preoperative radiotherapy RT is widely used as the initial treatment for locally advanced rectal cancer RC in the neoadjuvant setting factors determining clinical response have not been adequately defined. Radiosensitivity has recently been shown to be greatly affected by immune function of the host. Methods In 48 cases of advanced RC we retrospectively examined the density of tumor infiltrating CD4 and CD8 T cells using immunohistochemical staining of biopsy samples before CRT and examined the correlation with tumor response. Results The numbers of both CD4 and CD8 tumor-infiltrating lymphocytes TIL in pre-CRT biopsy samples were strongly correlated with tumor reduction ratio evaluated by barium enema. Moreover the densities of CD4 and CD8 TIL were significantly associated with histological grade after CRT. The density of CD8 TIL was an independent prognostic factor for achieving complete response after CRT. Conclusions In RC patients T lymphocyte-mediated immune reactions play an important role in tumor response to CRT and the quantitative measurement of TIL in biopsy samples before CRT can be used as a predictor of the clinical effectiveness of CRT for advanced RC. Introduction Previous studies have demonstrated that preoperative radiotherapy RT can produce down-staging in advanced rectal cancer RC resulting in longer survival a reduced rate of postoperative local recurrence. Recently adding chemotherapy to RT CRT has achieved even more favorable results 1-3 . Thus preoperative RT in the neoadjuvant setting is currently recognized as the standard treatment for locally advanced RC. However in unresponsive